Parsimonious DNA target-site recognition by Grh/CP2 transcription factors
نویسندگان
چکیده
منابع مشابه
Thermodynamics of DNA target site recognition by homing endonucleases
The thermodynamic profiles of target site recognition have been surveyed for homing endonucleases from various structural families. Similar to DNA-binding proteins that recognize shorter target sites, homing endonucleases display a narrow range of binding free energies and affinities, mediated by structural interactions that balance the magnitude of enthalpic and entropic forces. While the bala...
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Sequence preferences of DNA binding proteins are a primary mechanism by which cells interpret the genome. Despite the central importance of these proteins in physiology, development, and evolution, comprehensive DNA binding specificities have been determined experimentally for only a few proteins. Here, we used microarrays containing all 10-base pair sequences to examine the binding specificiti...
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Transcription factors play essential role in the gene regulation in higher organisms, binding to multiple target sequences and regulating multiple genes in a complex manner. In order to understand the molecular mechanism of target recognition, and to predict target genes for transcription factors at the genome level, it is important to analyze the relationship between the structure and function...
متن کاملDNA recognition code of transcription factors.
Introduction Over 35 years have passed since the ‘central dogma’ of molecular biology (DNA makes RNA makes protein) was proposed (Crick, 1958). Despite its remarkable verification, it is being seen increasingly as limited, for if the whole flow of information in a cell were unidirectional, all cells with the same complement of genetic material would have identical function and morphology. The t...
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The bacterial transposon Tn7 inserts at high frequency into a specific site called attTn7, which is present in the chromosomes of many bacteria. We show here that transcription of a nearby gene, glmS, decreases the frequency of Tn7 insertion into attTn7, thus providing a link between Tn7 transposition and host cell metabolism.
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ژورنال
عنوان ژورنال: Acta Crystallographica Section A Foundations and Advances
سال: 2017
ISSN: 2053-2733
DOI: 10.1107/s2053273317092750